Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
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Zhongguo Yi Xue Ke Xue Yuan Xue Bao · Apr 2010
[Establishment of a new rat model of chronic cyclosporine A nephrotoxicity].
To establish a new rat model of chronic cyclosporine A nephrotoxicity and explore its features. ⋯ We successfully established a new rat model of chronic CsA nephrotoxicity by adrenalectomy without low sodium diet. After adrenalectomy, local renal aldosterone in kidney may compensate for circulatory aldosterone deficit to maintain electrolyte balance.