Journal of diabetes science and technology
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J Diabetes Sci Technol · Sep 2008
An electronic protocol for translation of research results to clinical practice: a preliminary report.
We evaluated the feasibility of using an electronic protocol developed for research use (Research-eProtocol-insulin) for blood glucose management in usual intensive care unit clinical practice. ⋯ Our electronic blood glucose protocol enabled translation of a research decision-support tool (Research-eProtocol-insulin) to usual clinical practice (Clinical-eProtocol-insulin).
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J Diabetes Sci Technol · Sep 2008
Analysis, modeling, and simulation of the accuracy of continuous glucose sensors.
Continuous glucose monitors (CGMs) collect a detailed time series of consecutive observations of the underlying process of glucose fluctuations. To some extent, however, the high temporal resolution of the data is accompanied by increased probability of error in any single data point. Due to both physiological and technical reasons, the structure of these errors is complex and their analysis is not straightforward. In this article, we describe some of the methods needed to obtain a description of the sensor error that is detailed enough for simulation. ⋯ CGM accuracy was modeled via diffusion and additive ARMA noise, which allowed for designing a computer simulator of sensor errors. The simulator, a component of a larger simulation platform approved by the Food and Drug Administration in January 2008 for pre-clinical testing of closed-loop strategies, has been successfully applied to in silico testing of closed-loop control algorithms, resulting in an investigational device exemption for closed-loop trials at the University of Virginia.