Acta ophthalmologica Scandinavica
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Acta Ophthalmol Scand · Dec 2006
Simultaneous quantification of 17 immune mediators in aqueous humour from patients with corneal rejection.
To simultaneously quantitate and compare the concentrations of 17 immune mediators: (1) the cytokines interleukin-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-10, IL-12p70, IL-13, IL-17, tumour necrosis factor-alpha, interferon-gamma; (2) the growth factors granulocyte-monocyte colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF), and (3) the chemokines CXCL-8, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1beta in aqueous humour from patients with corneal rejection and patients with a non-inflammatory condition in the anterior chamber. ⋯ The Luminex 100 multiplex array assay is very efficient in simultaneous quantitation of multiple immune mediators in small volumes of aqueous humour. A total of 17 immune mediators were increased in aqueous humour from rejection patients. This underlines the complex immunological interactions of the rejection process.
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Acta Ophthalmol Scand · Dec 2006
Case ReportsIsolated bilateral optic neuritis in acute disseminated encephalomyelitis.
We present a 4-year-old girl with isolated visual loss related to a bilateral oedematous optic neuropathy of unknown origin, occurring after an episode of viral illness. ⋯ Bilateral isolated optic neuritis in childhood may be the only presenting symptom in acute disseminated encephalomyelitis, which requires appropriate evaluation and therapeutic management.