Gan to kagaku ryoho. Cancer & chemotherapy
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Gan To Kagaku Ryoho · Sep 1994
Multicenter Study Clinical Trial Controlled Clinical Trial[Phase I clinical trial of RP 56976 (docetaxel) a new anticancer drug].
A multicenter phase I clinical trial of RP 56976 (docetaxel), a new anticancer drug, was performed with single and repeated doses. Based on the results of phase I clinical trials conducted in the United States and Europe, the starting dose was 10 mg/m2. The dose was subsequently increased to 20, 50, 70 and 90 mg/m2. ⋯ The white blood cell count reached a nadir about 9.5-19.5 days (median) after administration, and took 7-11 days (median) to recover. Other adverse reactions observed were nausea/vomiting anorexia, alopecia, diarrhea, fatigue and fever, which were all acceptable. The results of this trial suggest that a dosage regimen of 60 mg/m2 at 3- to 4 week intervals is appropriate in an early phase II clinical trial.
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Gan To Kagaku Ryoho · Sep 1994
Clinical Trial Controlled Clinical Trial[The effect of intraperitoneal and intra-aortic chemotherapy for unresectable gastric cancer].
Regional chemotherapy was given 16 unresectable gastric cancer patients. Two types of the chemotherapy, intraperitoneal (IP) and intraaortic (IA) administration, were carried out. The control group was comprised of 17 patients. ⋯ IP showed a significantly longer survival rate than controls (p < 0.001). All but one patient was able to stay at home. Intraperitoneal chemotherapy showed both local and systemic effects in unresectable gastric cancer.
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Gan To Kagaku Ryoho · Sep 1994
Case Reports[Hepatic arterial infusion therapy in a patient with multiple hepatic metastases from gastric cancer].
A patient with multiple hepatic metastases (H3) from advanced gastric cancer was treated with pre- and post-operative arterial infusion therapy. A Port-A-Cath was cannulated into the gastroduodenal artery after total gastrectomy. ⋯ The patient has been alive for 15 months after the operation without any complaint. Arterial infusion chemotherapy through implantable reservoir is useful for the treatment of unresectable hepatic metastasis without decreasing the quality of life.
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Gan To Kagaku Ryoho · Sep 1994
Clinical Trial[Evaluation of cases of metastatic liver tumors resected following intra-arterial infusion chemotherapy].
We encountered four cases whose unresectable metastatic liver tumors could be resected by operation after intra-arterial infusion chemotherapy using an implantable reservoir. Metastatic lesions were thus markedly reduced and localized. Three cases were metastases of colorectal cancer and one of gastric cancer. ⋯ Our results indicate that this chemotherapy could be a neoadjuvant chemotherapy for unresectable metastatic liver tumors which may become resectable after this chemotherapy as seen in our cases. However, lung metastases and peritoneal dissemination influenced the prognosis of our cases. Treatment of extra-hepatic recurrence seemed important to improve the prognosis of these patients.