Gan to kagaku ryoho. Cancer & chemotherapy
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Breast cancer is one of the most common malignancies among Japanese women. Approximately 40,000 new patients are diagnosed annually. ⋯ It was widely accepted that for breast cancer as a systemic disease, appropriate systemic treatment of either chemotherapy and endocrine therapy improved the survival. We describe here the contributions of new agents to the improvement in survival for breast cancer patients and introduced the concept of dose density.
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Gan To Kagaku Ryoho · Jun 2006
Review[Timeline from discovery of 5-FU to development of an oral anticancer agent S-1 and its drug concept].
C. Heidelberger et al left great gifts to us. Approximately 50 years have elapsed since their discovery of 5-FU in 1957 before eventually elucidating the mechanisms by which the drug exerts its pharmacological actions and provokes its adverse reactions. ⋯ From 2001 to 2005, S-1 was approved for the treatment of head and neck cancer, colon cancer, non-small cell lung cancer, and breast cancer. S-1 has been applied to acquire its expanded indications for the treatment of pancreatic cancer and biliary tract cancer. We are confident that the combined regimen of S-1 with other anticancer agents and with other therapeutic modalities will contribute to the routine medical practice of cancer treatment in the future.