Gan to kagaku ryoho. Cancer & chemotherapy
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Gan To Kagaku Ryoho · Apr 2010
Case Reports[Successful desensitization protocol for patients with hypersensitivity reactions caused by carboplatin].
We report the successful desensitization of a patient with a hypersensitivity reaction to carboplatin. A 54-year-old woman with advanced ovarian cancer went into remission after 10 courses of paclitaxel plus carboplatin (TC). After 7 months, cancer recurred in the vaginal cuff, and surgery was performed. ⋯ The desensitization procedure was successful, and the patient subsequently tolerated four additional courses of TC, with no further signs or symptoms of hypersensitivity. A complete response was achieved. A carboplatin desensitization regimen may allow patients with platinum-sensitive ovarian cancer to continue to benefit from therapy.