Gan to kagaku ryoho. Cancer & chemotherapy
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Gan To Kagaku Ryoho · Jan 2018
[Treatment of Regorafenib in Patients with Metastatic or Unresectable Gastrointestinal Stromal Tumor after Failure of Imatinib and Sunitinib].
Imatinibmesylate has dramatically improved the survival with unresectable or metastatic GIST, whereas many patients subsequently develop imatinib resistance. Followed by sunitinib, regorafenib has been approved since 2013 in Japan. We aimed to assess efficacy and safety of regorafenibin GIST patients in clinical setting. ⋯ The most common Grade 3 toxicity was hand-and-foot skin reactions(4 of 11; 36.4%), followed by hypertension(3 of 11; 27.3%). Dose reduction was required in 8 patients. Although dose modifications due to toxicities were very common, some patients achieved long PFS with regorafenibtreatment.