Gan to kagaku ryoho. Cancer & chemotherapy
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Gan To Kagaku Ryoho · Nov 2012
Case Reports[A case of advanced breast cancer in which quality of life was improved by Mohs' paste and hormone therapy].
We report a case of breast cancer hemorrhage locally controlled with zinc chloride paste (Mohs' paste), which is usually applied as a fixative for 24 h before micrographic surgery of cutaneous neoplasms. A 73-year-old woman was suffering from continuous bleeding from an advanced right breast cancer; this bleeding stopped after 15 min by hemostatic treatment with Mohs' paste. ⋯ The tumor size has been locally controlled for 2 years. This rapid treatment with Mohs' paste is effective for controlling bleeding and breast tumor exudates without adverse events, and improves the patients' quality of life.
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Gan To Kagaku Ryoho · Nov 2012
Case Reports[A case of recurrent gastrointestinal stromal tumor with complete response from treatment with reduced dose of imatinib mesylate].
We report a patient who had a complete response by treatment with 200 mg of imatinib mesylate daily for peritoneal recurrences of gastrointestinal stromal tumor(GIST)of the stomach. On March 2007, a 68-year-old woman underwent distal gastrectomy for GIST of the stomach. ⋯ After reduction of imatinib mesylate, the adverse reactions resolved. Peritoneal dissemination disappeared on CT scan from April 2010, and complete response has been maintained for 18 months.
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Gan To Kagaku Ryoho · Oct 2012
[Prevention of nausea and vomiting in pain medication for digestive cancer].
Nausea and vomiting are common side effects due to opioid therapy, and may greatly impede the quality of life of cancer patients. A preventive method for nausea and vomiting has not yet been established. We developed a clinical pathway(CP) for cancer pain management in which prochlorperazine is used for the prevention of nausea and vomiting caused by opioids. ⋯ The incidence of nausea and vomiting of those patients was 15. 8% which was lower than the results of other previous clinical trials. However, we could not show the effectiveness of prochlorperazine. Prochlorperazine, which is a dopamine D2 receptor antagonist, may show limited utility for the prevention of nausea and vomiting; however, in opioid therapy, histamine receptor(H1)prevention is also important.
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Gan To Kagaku Ryoho · Oct 2012
[Hyperglycemia due to atypical antipsychotics in cancer patients with delirium].
We investigated hyperglycemia due to atypical antipsychotics in cancer patients with delirium. Using patient records retrospectively, we investigated 189 cancer patients who were diagnosed with delirium between June 2008 and May 2009. ⋯ Three percent(5/154)of them were admitted with over 350 mg/dL blood glucose during their atypical antipsychotics treatment, however, all cases did not relate the adverse reaction of hyperglycemia with the use of antipsychotics. Most cancer patients with delirium used atypical antipsychotics, and the incidence of hyperglycemia was low.