Gan to kagaku ryoho. Cancer & chemotherapy
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Gan To Kagaku Ryoho · Mar 2015
Case Reports[Case report of disseminated carcinomatosis of the bone marrow originating from gastric cancer with cancer-related disseminated intravascular coagulation successfully treated with recombinant human soluble thrombomodulin].
A 62-year-old man, who underwent distal gastrectomy due to gastric cancer, was diagnosed with disseminated carcinomatosis of the bone marrow 8 years later. Chemotherapy was administered following treatment with recombinant human soluble thrombomodulin (rTM), and as a result, he successfully recovered from his disseminated intravascular coagulation (DIC) status and experienced improvement of his severe cancer-related pain. The use of rTM may enable the safe continuation of chemotherapy, and rTM may also be a useful treatment for DIC associated with solid cancer, such as gastric cancer.
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Gan To Kagaku Ryoho · Feb 2015
[Heavy ion radiotherapy for prostate cancer -- the role of hormone therapy].
The role of androgen deprivation therapy combined with heavy ion radiotherapy involving carbon ions was reviewed. In conventional radiotherapy, short- and long-term androgen deprivation therapies were recommended for patients with intermediate- and high-risk prostate cancers, respectively. ⋯ Heavy ion radiotherapy and androgen deprivation therapy were performed in combination according to risk criteria. Further studies are warranted to determine the optimal method and duration of androgen deprivation therapy during heavy ion radiotherapy for prostate cancer.
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Of late, there has been rapid development of chemotherapeutic agents for treating metastatic colorectal cancers. However, the so-called "druglag" is a long-standingproblem; it refers to the drugapproval delays in Japan that occur after drugs have been developed and approved in Europe and the USA. ⋯ Data from the global phase III RECOURSE trial were presented in the ESMO-GI 2014, where the efficacy of TAS-102 was proved again. Herein, we present data about the efficacy and side effects of TAS-102 from each clinical trial.
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Gan To Kagaku Ryoho · Nov 2014
Case Reports[A case of ARDS after esophagectomy treated with low-dose steroid therapy].
A 48-year-old woman was found to have an esophageal cancer, and after preoperative chemotherapy with cisplatin (CDDP)/5-fluorouracil (5-FU), radical subtotal esophagectomy was performed. On the fifth day after surgery, her respiratory condition suddenly worsened and a chest radiograph showed low permeability in both lung fields, leading to a diagnosis of acute respiratory distress syndrome (ARDS) and intubation for mechanical ventilation. Since clinical examination did not detect signs of infection on the seventh day, we began administering hydrocortisone at a dose of 300 mg. ⋯ ARDS remains a refractory disease and no drug has proven to be effective in randomized controlled trials. The use of steroids for ARDS management remains controversial. Our present case suggests that low-dose steroids from an early stage in uninfected ARDS patients may improve prognosis.
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Gan To Kagaku Ryoho · Nov 2014
[Laparoscopic hemi-double stapling and reduced-port laparoscopic distal gastrectomy for gastric cancer].
The hemi-double stapling method (HDS) is typically used for extracorporeal Billroth-I anastomosis. We used HDS for reduced-port surgery. Laparoscopic HDS is used for intracorporeal Billroth-I anastomosis after laparoscopic distal gastrectomy. We performed reduced-port laparoscopic distal gastrectomy for gastric cancer. ⋯ Laparoscopic HDS and reduced-port laparoscopic distal gastrectomy are safe and feasible procedures.