Lijec̆nic̆ki vjesnik
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Lijec̆nic̆ki vjesnik · Jul 1999
Review[Development of beta-lactam antibiotic resistance in gram-negative bacteria and the impact of resistance on therapy].
Bacterial resistance to antibiotic is the inevitable consequence of the utilization of antimicrobial agents all over the world, particularly in developed countries. It is particularly evident with beta-lactam agents because they are among most frequently prescribed drugs. The resistance is mainly attributable to production of various types of beta-lactamases but other mechanisms like alterations in PBP molecules or in outer membrane proteins can play a significant role. ⋯ Recently, the emergence of E. coli strain resistant to combination of amoxycillin and clavulanate, due to hyperproduction of TEM-1 beta-lactamase, was observed. Inducible beta-lactamases mediate beta-lactam resistance in Pseudomonas aeruginosa which often develops during therapy of P. aeruginosa infections. Imipenem resistance is increasingly prevalent among P. aeruginosa isolates nowadays, but can be detected in K. pneumoniae due to the production of novel beta-lactamases and changes in outer membrane proteins.
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Lijec̆nic̆ki vjesnik · Jul 1999
Biography Historical Article[The role of Dr. Vladimir Cepulić in Croatian orthopedics].
Professor B. Spisić is rightly referred to as founder of the Croatian orthopaedics and rehabilitation. Based on the principles formulated by Prof. ⋯ Cepulić became a famous Croatian physiologist. Owing to his contribution in fighting tuberculosis in Croatia, as well as his merits for the Croatian Medical Association, he is among the most prominent Croatian doctors. On this occasion, the memory of his place in the history of Croatian orthopaedics, that is less known, is refreshed.