Lijec̆nic̆ki vjesnik
-
Lijec̆nic̆ki vjesnik · Jul 2003
Historical Article[The Journal of Slavonian Physicians (Glasnik druztva Slavonskih Liecnika), the journal of the medical society in Croatia 1877-1878].
If we discuss chronological appearance of medical journals as official gazettes of medical associations in this part of the world and Europe, then Glasnik druztva slavonskih liecnika (Glasnik DSL) is the first and the oldest medical journal of this kind in Croatia, whose first number is dated January 1, 1877, and the last December 1, 1878. It is the gazette of the Slavonian Medical Association in Osiek (DSL in Osiek), a professional medical association founded in 1874, which today marks its activity as the Croatian Medical Association--Osijek Branch (HLZ). Our goal was to investigate the key determinants of its appearance in the context of the role and contribution of Slavonian physicians in the promotion and development of Croatian medical literature, particularly medical periodicals in the 19th century. ⋯ The results are presented in several separate chapters which offer new scientific knowledge about the history of the medical Journal Glasnik DSL, and about the role of Slavonian physicians and DSL in Osiek in the promotion of Croatian medical terminology and the development of professional medical literature from the middle of the 19th century through 1878. In Glasnik DSL we today recognize our first medical periodical as the oldest scientific and professional gazette of the medical association; the unique source and material for studying the history of Croatian medical journals; history of medical associations; health-related circumstances, conditions of work and striving of physician, and professional and scientific scopes in Croatia in the 19th century. Each number is by itself a value and a bibilographic rarity, all numbers together represent a unique monument to Croatian medical heritage, whose availability for the new generations is facilitated by publishing the reprint issue in 1999.
-
Lijec̆nic̆ki vjesnik · Jul 2003
Clinical Trial[Treatment of chronic myeloid leukemia with imatinib in the accelerated stage of the disease].
Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML), in advanced stage of disease, is resistant to standard chemotherapy. Imatinib was found to be effective in these patients. This paper shows our preliminary results. ⋯ After a 9-month follow up Ph+ CML progressed in 9 patients (60%) and 4 of them died. The most frequent adverse effects were edema, nausea, neutropenia and thrombocytopenia. Imatinib mesylate has a substantial, but short term activity in the accelerated phase and blastic crisis of the Ph+ CML.