Molecular biology reports
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Molecular biology reports · Jul 2013
Review Meta AnalysisQuantitative analysis of the association between interleukin-10 1082A/G polymorphism and susceptibility to sepsis.
There are some epidemiological studies investigating the association between interleukin-10 (IL-10) 1082A/G polymorphism and sepsis susceptibility reporting conflicting findings. Our work tried to further quantitatively assess the association of the IL-10 1082A/G polymorphism with sepsis susceptibility through a systematic review and meta-analysis. A total of eleven studies with 2,528 subjects were finally included into the meta-analysis. ⋯ Subgroup analysis by ethnicity showed that there was an obvious association between IL-10-1082A/G polymorphism and sepsis susceptibility in Asians under three comparison models (for G vs A: OR = 0.75, 95 % CI 0.62-0.91, P = 0.004; for GG vs AA: OR = 0.39, 95 % CI 0.21-0.73, P = 0.003; for GG vs AA/AG: OR = 0.36, 95 % CI 0.14-0.92, P = 0.032), but there was no similar association in Caucasians under all four comparison models. Our meta-analysis reveals that the IL-10-1082A/G polymorphism has an association with the susceptibility to sepsis in Asian populations. Further studies are needed to investigate the effect of IL-10-1082A/G polymorphism on sepsis susceptibility in Caucasians.
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Molecular biology reports · Jul 2013
Review Meta AnalysisQuantitative analysis of the association between interleukin-10 1082A/G polymorphism and susceptibility to sepsis.
There are some epidemiological studies investigating the association between interleukin-10 (IL-10) 1082A/G polymorphism and sepsis susceptibility reporting conflicting findings. Our work tried to further quantitatively assess the association of the IL-10 1082A/G polymorphism with sepsis susceptibility through a systematic review and meta-analysis. A total of eleven studies with 2,528 subjects were finally included into the meta-analysis. ⋯ Subgroup analysis by ethnicity showed that there was an obvious association between IL-10-1082A/G polymorphism and sepsis susceptibility in Asians under three comparison models (for G vs A: OR = 0.75, 95 % CI 0.62-0.91, P = 0.004; for GG vs AA: OR = 0.39, 95 % CI 0.21-0.73, P = 0.003; for GG vs AA/AG: OR = 0.36, 95 % CI 0.14-0.92, P = 0.032), but there was no similar association in Caucasians under all four comparison models. Our meta-analysis reveals that the IL-10-1082A/G polymorphism has an association with the susceptibility to sepsis in Asian populations. Further studies are needed to investigate the effect of IL-10-1082A/G polymorphism on sepsis susceptibility in Caucasians.