MedGenMed : Medscape general medicine
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To describe allergic asthma and allergic rhinitis pathophysiology and review the pharmacologic, pharmacokinetic, pharmacodynamic, efficacy, and safety data for omalizumab. ⋯ Omalizumab has demonstrated efficacy in children, adults, and adolescents with uncontrolled moderate to severe allergic asthma and allergic rhinitis. Long-term safety beyond 52 weeks needs continued evaluation.
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Review Case Reports
Group A beta-hemolytic streptococcal glossal necrotizing myositis--case report and review.
We report the first case of glossal necrotizing myositis by group A beta-hemolytic Streptococcus in an 8-year-old girl on chronic nonsteroidal anti-inflammatory drugs, immunomodulators, and steroids for juvenile rheumatoid arthritis. Treatment included partial glossectomy and parenteral antibiotics. After a critical course, full recovery ensued. The subject of necrotizing myositis is reviewed.
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Injuries from marine life encompass a wide spectrum, from mild stings to severe bites. Fortunately most of the injuries are mild, although some may be significant, resulting in death. Most of these injuries can be treated by family physicians with a knowledge of the cause of the pathology. ⋯ Coral, sea bathers eruption, and swimmer's itch require thorough scrubbing and irrigation. Sea snakes, cone shells, and venomous fish possess a neurotoxin that requires close monitoring in the event of cardiopulmonary collapse. All of these injuries require tetanus status monitoring and consideration of coverage for infectious sequelae.
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Chronic pain is a frequent medical condition that has a significant impact on patients, including their ability to function and enjoy life. In addition, chronic pain has a substantial economic impact on the workplace and costs of healthcare. ⋯ By understanding those times of day and activities that may precipitate severe episodes of pain, tailored opioid treatment plans can be developed that manage pain, improve patient functionality, and minimize side effects. Recently developed rapid-onset opioid formulations should be considered as part of the chronic pain management strategy in addition to more traditional long-acting, sustained-release formulations and short-acting, normal-release formulations.