Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Conf Proc IEEE Eng Med Biol Soc · Jan 2008
Thermal effect of sonophoresis for accelerating the analgesic effect of local anesthetics on rat tail nerve.
Sonophoresis is an ultrasound transdermal drugs delivery system. The eutectic mixture of local anesthetics (EMLA) has been used clinically for anesthesia but requires at least one hour to take effect and lacks of analgesia's objective assessment. We proposed that sonophoresis could reduce the duration of EMLA analgesia effect onset and be assessed by sensory conduction studies. ⋯ We have objectively examined the sonophoresis effect of ultrasound by investigating the effects of EMLA. Applying ultrasound for 5 min reduces the onset time of EMLA analgesia from 60 min to less than 20 min. Ultrasound sonophoresis of analgesic drugs is potentially useful in the treatment of carpal tunnel syndrome, tooth extraction, and other applications of analgesia.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2008
Clinical TrialValidation of the Index of Consciousness (IoC) during sedation/analgesia for ultrasonographic endoscopy.
The level of consciousness of patients undergoing surgery evolves continuously as the effect of the anesthetic agents is counteracted by the surgical stimuli. The monitors of depth of anesthesia, based on the analysis of the electroencephalogram (EEG), have been progressively introduced into the daily practice to provide additional information about the state of the patient. ⋯ A good correlation is found between both indexes. Furthermore, IoC presents a significantly higher prediction probability Pk of the level of sedation than BIS, and can thus be considered as an interesting measure of the level of consciousness.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2008
Comparative StudyPerformance evaluation of three methods for respiratory signal estimation from the electrocardiogram.
A comparative study of three methods for estimating respiratory signal through electrocardiogram (ECG) was carried out. The three methods analyzed were based on R wave area, R peak amplitude and heart rate variability (HRV). For each method, cross-correlation coefficient and spectral coherence in a range of frequencies up to 0.5 Hz were computed between the ECG derived respiratory signals (EDR) and the three real respiratory signals: oronasal, and two inductance plethysmographies recordings (chest and abdominal). Results indicate that EDR methods based on R wave area and HRV are better correlated and show a wider spectral coherence with real respiratory signals than the other EDR method based on R peak amplitude.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2008
Clinical TrialA neuro-fuzzy approach for predicting hemodynamic responses during anesthesia.
The effect of drugs' interaction on the hemo-dynamic variables is of great importance when considering patient's safety and stability. It is also important for control infusion systems during anesthesia. ⋯ The use of subtractive clustering improved the model performance on the testing data set. The fuzzy model is able to capture the synergistic interaction between the two drugs, but other influences were detected.