Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Conf Proc IEEE Eng Med Biol Soc · Jan 2011
Instrumentation to record evoked potentials for closed-loop control of deep brain stimulation.
Closed-loop deep brain stimulation (DBS) systems offer promise in relieving the clinical burden of stimulus parameter selection and improving treatment outcomes. In such a system, a feedback signal is used to adjust automatically stimulation parameters and optimize the efficacy of stimulation. We explored the feasibility of recording electrically evoked compound action potentials (ECAPs) during DBS for use as a feedback control signal. ⋯ Subsequently, the instrumentation was used to make in vivo recordings of ECAPs during thalamic DBS in cats, without contamination by the stimulus artifact. The signal characteristics were similar across three experiments, suggesting common neural activation patterns. The ECAP recordings enabled with this novel instrumentation may provide insight into the type and spatial extent of neural elements activated during DBS, and could serve as feedback control signals for closed-loop systems.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2011
Effect of functional electrical stimulation (FES) combined with robotically assisted treadmill training on the EMG profile.
Functional electrical stimulation (FES) is used to assist spinal cord injury patients during walking. However, FES has yet to be shown to have lasting effects on the underlying neurophysiology which lead to long-term rehabilitation. ⋯ Rats who received this FES therapy during a 2-week training period exhibited peak EMG activity during the appropriate phase of the gait cycle; whereas, rats who received stimulation which was randomly timed with respect to their motor activity exhibited no clear pattern in their EMG profile. These results from our newly developed FES system serve as a launching point for many future studies to test and understand the long-term effect of FES on spinal cord rehabilitation.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2011
Robust video-oculography for non-invasive autonomic nerve quantification.
A relationship between autonomic nerves activity and depression or Alzheimer's disease has been reported. The quantification of autonomic nerves is expected to serve as a tool for quantifying the of severity of the disease or for early detection. Video-oculography is known as a non-invasive and reliable procedure of measurement of pupil response and is used in clinical practice. ⋯ In this study, we developed a robust and accurate method to measure the transition of pupil size. The proposed method introduces an interpolation process using an active contour model and ellipse estimation with selection of reliable contour points and attains robust measurement of pupil area against the abovementioned difficulties. We confirmed our method achieved an extraction accuracy of 98.3 % in precision and 98.9% in recall in average on the tested a total of 8,518 image frames from 30 movies.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2011
Respiratory rate estimation using respiratory sinus arrhythmia from photoplethysmography.
Respiratory rate (RR) is an important measurement for ambulatory care and there is high interest in its detection using unobtrusive mobile devices. For this study, we investigated the estimation of RR from a photoplethysmography (PPG) signal that originated from a pulse oximeter sensor and had a sub-optimal sampling rate. We explored the possibility of estimating RR by extracting respiratory sinus arrhythmia (RSA) from the PPG-derived heart rate variability (HRV) measurement using real-time algorithms. ⋯ Both PPG and ECG RR estimation techniques were more powerful and reliable in cases of spontaneous ventilation than when pressure controlled ventilation was used. The analysis of cases containing artifacts in the PPG revealed a significant increase in RR error, a trend that was less pronounced for controlled ventilation. These results indicate that the estimation of RR from the sub-optimally sampled PPG signal is possible and more reliable than from the ECG.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2011
Training to improve volitional muscle activity in clinically paralyzed muscles for neuroprosthesis control.
Neuroprostheses are devices that use electrical stimulation to activate paralyzed muscles in a coordinated manner to restore functional movements. These systems utilize a voluntarily-generated command signal for control of function. Current command signals include electromyographic (EMG) activity from muscles above the injury level that remain under volitional control. ⋯ Our recent research suggests that volitional muscle activity from below the injury level in individuals with motor complete spinal cord injury may be a viable source of command information. The signals from these muscles are small, and therefore the goal of this study is to determine if training using visual feedback can improve the quality of these muscle signals. Results to date indicate that training with visual feedback can increase both the magnitude and consistency of EMG signals in clinically paralyzed muscles.