Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Conf Proc IEEE Eng Med Biol Soc · Jan 2011
Phase-based measures of cross-frequency coupling in brain electrical dynamics under general anesthesia.
The state of general anesthesia (GA) is associated with an increase in spectral power in scalp electroencephalogram (EEG) at frequencies below 40 Hz, including spectral peaks in the slow oscillation (SO, 0.1-1 Hz) and α (8-14 Hz) bands. Because conventional power spectral analyses are insensitive to possible cross-frequency coupling, the relationships among the oscillations at different frequencies remain largely unexplored. Quantifying such coupling is essential for improving clinical monitoring of anesthesia and understanding the neuroscience of this brain state. ⋯ The waking and two distinct states under GA could be discriminated by projecting in a two-dimensional phase space defined by the SynchFastSlow and the preferred SO phase of α activity. Our results show that a stereotyped pattern of phase-amplitude coupling accompanies multiple stages of anesthetic-induced unconsciousness. These findings suggest that modulogram analysis can improve EEG based monitoring of brain state under GA.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2011
The center for integration of medicine and innovative technologies (CIMIT): a proven model to speed the cycle of healthcare innovation.
CIMIT is a Boston-wide consortium of premier clinical, research and academic institutions dedicated to improving patient care through application of innovative enabling technology.
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Burst suppression is an electroencephalogram pattern observed in states of severely reduced brain activity, such as general anesthesia, hypothermia and anoxic brain injuries. The burst suppression ratio (BSR), defined as the fraction of EEG spent in suppression per epoch, is the standard quantitative measure used to characterize burst suppression. ⋯ Our approach removes the need to artificially average the ratio over long epochs and allows us to make formal statistical comparisons of burst activity at different time points. Our state-space model suggests a more principled way to analyze this key EEG feature that may offer more informative assessments of its associated brain state.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2011
Using ultrasound imaging to identify landmarks in vertebra models to assess spinal deformity.
Scoliosis is a type of spinal deformity that commonly develops in adolescents. Cobb angle, using the most tilted vertebrae, is the gold standard to assess scoliosis on radiographs. However, regularly taking radiographs introduces harmful ionizing radiation to patients, thus non-ionizing radiation methods have been explored for many years. ⋯ The second study showed laminae and transverse processes could be recognized from ultrasound images. The difference of the width of the laminae between the phantom and the ultrasound image was 0.3 mm. Therefore, it is feasible to use the proposed method and the laminae from the ultrasound images to assess the severity of scoliosis.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2011
iSyNCC: an intelligent system for patient monitoring & clinical decision support in Neuro-Critical-Care.
Close monitoring and timely treatment are extremely crucial in Neuro Intensive/Critical Care Units (NICUs) to prevent patients from secondary brain damages. However, the current clinical practice is labor-intensive, prone to human errors and ineffective. ⋯ The requirements of the system were investigated through interviews and discussions with neurosurgeons, neuroclinicians and nurses. Based on the summarized requirements, a modular 2-tier system is developed. iSyNCC integrates and stores crucial patient information ranging from demographic details, clinical & treatment records to continuous physiological monitoring data. iSyNCC enables remote and centralized patient monitoring and provides computational intelligence to facilitate clinical decision makings.