Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
Hemodynamics at the ostium of cerebral aneurysms with relation to post-treatment changes by a virtual flow diverter: a computational fluid dynamics study.
Computational fluid dynamics (CFD) techniques have been refined for modeling the hemodynamics in cerebral aneurysms. Recent interest has focused on understanding hemodynamic changes by treatment with a flow diverter (FD), i.e. a stent with a dense metal mesh which is placed across the ostium to divert the majority of flow away from the aneurysm. Potential complications include remnant inflow jets but, more seriously, aneurysm hemorrhage. ⋯ Velocities and WSS were reduced in all cases post FD treatment, pressure increased in one case. Heterogeneous distributions of the velocity magnitude were found at the ostium with focal maxima indicating potential risk zones for remnant inflow jets into the aneurysms. Pressures at the ostium correlated with pressure changes inside the aneurysm which could become a pre-treatment indicator for the evaluation of the suitability of a particular aneurysm for FD treatment.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
Effects of low amplitude pulsed radiofrequency stimulation with different waveform in rats for neuropathic pain.
Pulsed-radiofrequency (PRF) electrical stimulation has been widely used for chronic pain treatment. It has been demonstrated with advantages of low temperature over traditional continuous radiofrequency (CRF) lesions with higher amplitude and mono polar electrode to treat pain in clinics (frequency 500 KHz, Pulse duration 20 msec, Amplitude 45 V, Treatment 2 min). ⋯ Experimental results of Von Frey Score show that the sinusoidal group has higher responses than the square wave one. Both fast and secondary expressed proteins of c-fos and pp38 are measured from spinal cord tissue sectioning slides to characterize the pain associated inflammatory responses and their responses due to PRF stimulation.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
Seizure prediction with bipolar spectral power features using Adaboost and SVM classifiers.
This paper presents the results of our study on finding a lower complexity and yet a robust seizure prediction method using intracranial electroencephalogram (iEEG) recordings. We compare two classifiers: a low-complexity Adaboost and the more complex support vector machine (SVM). Adaboost is a linear classier using decision stumps, and SVM uses a nonlinear Gaussian kernel. ⋯ The proposed methods were applied on 8 invasive recordings selected from the EPILEPSIAE database, the European database of EEG seizure recordings. Doublecross validation is used by separating data sets for training and optimization from testing. The key conclusion is that Adaboost performs slightly better than SVM using a reduced feature set on average with significantly less complexity resulting in a sensitivity of 77.1% (27 of 35 seizures in 873 h recordings) and a false alarm rate of 0.18 per hour.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
Effect of hypothermia on cortical and thalamic signals in anesthetized rats.
Beneficial effects of hypothermia on subjects with neuro-pathologies have been well demonstrated in both animal studies and clinical trials. Although it is known that temperature significantly impacts neurological injuries, the underlying mechanism remains unclear. We studied the effect of temperature modulation on neural signals in the cortex and the thalamus in uninjured brains of anesthetized rats. ⋯ In addition, our results showed that hypothermia significantly increased the burst suppression ratio (BSR) in EEG, cortical and thalamic signals by 3.42, 3.25, 7.29 times respectively (P<0.01), and prolonged the latency of neuronal response in cortex to median nerve stimulation from 9 ms to 16 ms (P<0.01). Furthermore, during normothermia, the correlation coefficient between thalamic and cortical signals was 0.35±0.02 while during hypothermia, it decreased to 0.16±0.03 with statistical significance (P<0.01). These results can potentially assist in better understanding the effects of hypothermia.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
Pilot investigation of anterior fontanelle photoplethysmographic signals and their suitability in estimating arterial oxygen saturation.
There is a need for more reliable, non-invasive and alternative measurement sites for the monitoring of arterial blood oxygen saturation in critically ill newborns at times of peripheral compromise. A pilot investigation on 14 Intensive Care Unit (ICU) newborns was conducted utilizing custom-made reflectance photoplethysmographic (PPG) sensors placed at the fontanelle and foot. The results suggest that the fontanelle is sensitive to changes in saturation, where saturation values obtained from the custom sensor were compared against commercial pulse oximeter values and results from a blood gas analyzer, however careful placement of the sensor at the fontanelle is an issue that needs further investigation.