Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Conf Proc IEEE Eng Med Biol Soc · Jan 2012
An elementary analysis of physiologic shock and multi-organ failure: the autodigestion hypothesis.
Physiological shock and subsequent multi-organ failure is one of the most important medical problems from a mortality point of view. No agreement exists for mechanisms that lead to the relative rapid cell and organ failure during this process and no effective treatment. We postulate that the digestive enzymes synthesized in the pancreas and transported in the lumen of the small intestine as requirement of normal food digestion play a central role in multi-organ failure. ⋯ Entry of the digestive enzymes into the wall of the intestine precipitates an autodigestion process as well as an escape of pancreatic enzymes and breakdown products generated by them into the system circulation. The consequence of autodigestion is multiorgan failure. We discuss the possibility to block the digestive enzymes in acute forms of shock as a potential therapeutic intervention.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats.
One of the important organ damage of hypertension is cognitive decline. Cognitive function is determined by the function of hippocampus, and previous studies have suggested that the decrease in brain-derived neurotrophic factor (BDNF) in the hippocampus causes cognitive decline. Protection against cognitive decline is reported not only in pharmacological therapy but also in exercise training or calorie restriction. ⋯ Exercise training for 28 days improved cognitive decline determined by Morris water maze test via up-regulation of BDNF in the hippocampus of stroke-prone spontaneously hypertensive rats, whereas calorie restriction for 28 days did not. However, exercise training plus calorie restriction causes the protection against cognitive decline to a greater extent than exercise training alone. In conclusion, exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in the hippocampus of stroke-prone hypertensive rats.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Case ReportsBrain state evolution during seizure and under anesthesia: a network-based analysis of stereotaxic eeg activity in drug-resistant epilepsy patients.
Epilepsy is a neurological condition with a prevalence of 1%, and 14-34% have medically refractory epilepsy (MRE). Seizures in focal MRE are generated by a single epileptogenic zone (or focus), thus there is potentially a curative procedure - surgical resection. This procedure depends significantly on correct identification of the focus, which is often uncertain in clinical practice. ⋯ Our preliminary study suggests that seizure foci may be the most weakly connected regions in the brain during the beginning of a seizure and the most strongly connected regions towards the end of a seizure. Additionally, in one of the patients analyzed, the network connectivity under anesthesia highlights seizure foci. Ultimately, network centrality computed from sEEG activity may be used to develop an automated, reliable, and computationally efficient algorithm for identifying seizure foci.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Clinical TrialReal-time cardiorespiratory coherence detects antinociception during general anesthesia.
Heart rate variability (HRV) may provide anesthesiologists with a noninvasive tool for monitoring nociception during general anesthesia. A novel real-time cardiorespiratory coherence (CRC) algorithm has been developed to analyze the strength of linear coupling between heart rate (HR) and respiration. CRC values range from 0 (low coherence, strong nociception) to 1 (high coherence, no nociception). ⋯ For comparison, three traditional measures of HRV (LF/HF ratio, SDNN, and RMSSD) responded on average by only 3.8%, 14%, and 3.9%, respectively. Finally, two traditional clinical measures of nociception (HR and blood pressure) responded on average by only 3.9% and 0.91%, respectively. CRC may thus be used as a real-time nociception monitor during general anesthesia.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Cortical potential imaging of somatosensory evoked potential induced by mechanical stimulation.
The objective evaluation of somatic sensations is expected without a patient's subjective opinions to reduce social problems such as those related to lawsuits for nerve injuries or malingering. In this study, the somatosensory evoked potential (SEP) using the mechanical stimulations of the tactile sensation was measured and analyzed in spatiotemporal domains. The cortical potential mapping projected onto the realistic-shaped model was estimated to improve the spatial resolution of the SEP maps by application of cortical dipole layer imaging. The experimentally obtained results suggest that the spatiotemporal distributions of the SEPs reflect the differences for positions, strengths, and patterns of somatosensory stimulations.