Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Conf Proc IEEE Eng Med Biol Soc · Jan 2014
Randomized Controlled TrialAltered cortical causality after remifentanil administration in healthy volunteers: a novel approach for pharmaco-EEG.
Alterations in cortical causality information flow induced by remifentanil infusion in healthy volunteers was investigated in a placebo-controlled double-blind cross-over study. For each of the 21 enrolled male subjects, 2.5 minutes of resting electroencephalography (EEG) data were collected before and after infusion of remifentanil and placebo. Additionally, to assess cognitive function and analgesic effect, continuous reaction time (CRT) and bone pressure and heat pain were assessed, respectively. ⋯ Furthermore, several of the PSI features altered by remifentanil were correlated to changes in both CRT and pain scores. The results indicate that remifentanil administration influence the information flow between several brain areas. Hence, the EEG causality approach offers the potential to assist in deciphering the cortical effects of remifentanil administration.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2009
Randomized Controlled TrialEffect of remifentanil on the nonlinear electroencephalographic entropy parameters in propofol anesthesia.
Nonlinear electroencephalographic entropy parameters have been proposed for the assessment of depth of anesthesia. The influence of remifentanil, a commonly used intraoperative opioid, on these parameters, namely approximate entropy (ApEn), sample entropy (SampEn), and permutation entropy (PeEn), during induction of propofol anesthesia was studied. ⋯ No consistent influence on PeEn was observed. However, this may have been due to strong interindividual variation in PeEn values.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2007
Randomized Controlled TrialA new method for evaluating the performance of depth-of-hypnosis indices - the D-value.
An alternative statistic, the D-value, is presented for the evaluation of the performance of EEG-based depth-of-hypnosis measures against the Observers' Assessment of Alertness/Sedation scale. The measures considered here are spectral entropy, approximate entropy, Lempel-Ziv complexity and Higuchi fractal dimension. The study is based on recordings from 45 patients, divided into three groups of 15 recordings each. ⋯ All the patients received stepwise increased dose of propofol. The study shows that the D-value is a promising and flexible statistic for the evaluation of the discriminative power of the EEG measures with respect to the OAA/S scale. The D-value indicates well the dependence of the performance of the measures on the EEG frequency band as well as on remifentanil concentration.