Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Conf Proc IEEE Eng Med Biol Soc · Jan 2010
Anaesthesia synchronization software: target controlled infusion system evaluation.
Target Controlled Infusion (TCI) systems are based in drug Pharmacokinetic (Pk) and Pharmacodynamic (Pd) models implemented in an algorithm to drive an infusion device. Several studies had compare manual titration of anesthesia and TCI system use; some studies evaluate the performance of the control algorithms for TCI systems, and a considerable number of studies assess the performance of Pk/Pd models implemented into TCI systems. ⋯ The goal of the current study was to assess the performance of the TCI system, Anaesthesia Synchronization Software (ASYS), on clinical set up to evaluate communication consistence (computer - infusion device) and controller performance in real time. These measures provided quantitative and qualitative evidences of software robustness and accuracy to be used at clinical environment.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2010
Effect of ECG quality measures on piecewise-linear trend detection for telehealth decision support systems.
Fledgling clinical decision support systems (DSSs) are being designed on the false assumption that consistent, good-quality signals are created in the unsupervised telehealth environment, but it has in fact been shown that signal quality is often very poor. Hence, it is important to investigate the detrimental impact of failing to recognize erroneous clinical parameter values. ⋯ The application of the same artifact detection also results in a significant improvement in trend fitting, when compared to a fitting of the reference HR values, by reducing the mean RMSE value of the error in the trend fit from 2.14 BPM to 0.78 BPM and standard error from 0.49 BPM to 0.10 BPM. As trend detection will be a component of future telehealth decision support systems, signal quality measures for unsupervised measurements are of paramount importance.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2010
Non lineal respiratory systems mechanics simulation of acute respiratory distress syndrome during mechanical ventilation.
Model and simulation of biological systems help to better understand these systems. In ICUs patients often reach a complex situation where supportive maneuvers require special expertise. ⋯ This work presents a model which can be simulated and use to help in training of physicians and respiratory therapists to analyze the respiratory mechanics in this kind of patients. We validated the model in 2 ARDS patients.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2010
Merging PK/PD information in a minimally parameterized model of the neuromuscular blockade.
A recursive system identification algorithm that merges PK/PD information in a minimally parameterized Wiener model for the NMB level is presented. The results show that the coupling between one parameter from the linear block and one from the static nonlinearity is advantageous, when evaluated on a database of 60 real collected NMB cases.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2010
Steering deep brain stimulation fields using a high resolution electrode array.
Deep brain stimulation (DBS) therapy relies on electrical stimulation of neuronal elements in small brain targets. However, the lack of fine spatial control over field distributions in current systems implies that stimulation easily spreads into adjacent structures that may induce adverse side-effects. ⋯ Our computational analysis demonstrates that the DBS-array is capable of accurately displacing activation volumes with sub-millimeter precision. Our findings demonstrate that future systems for DBS therapy may provide for more accurate target coverage than currently available systems achieve.