The Journal of the Association of Physicians of India
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J Assoc Physicians India · Feb 2021
Itolizumab Treatment for Cytokine Release Syndrome in Moderate to Severe Acute Respiratory Distress Syndrome Due to COVID-19: Clinical Outcomes, A Retrospective Study.
Hyperinflammation, hypercoagulation and multi-organ dysfunction are life-threatening complications needing immediate attention in moderate-tosevere COVID-19 patients. We present our real world experience with Itolizumab, a repurposed immunomodulatory monoclonal antibody, administered in COVID-19 patients. ⋯ A single dose of Itolizumab accelerated recovery in adult patients with COVID-19 by controlling immune hyperactivation. The clinical improvement was demonstrated by reduction in inflammatory markers, weaning off oxygen, reduced length of hospital stay and improvement of ordinal score. Itolizumab was well tolerated and when administered in the early phase of the inflammatory cascade is an efficient therapeutic option for treatment of cytokine release syndrome in moderate to severe COVID-19 patients.
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J Assoc Physicians India · Dec 2020
Beyond COVID-19: Evidence-Based Consensus Statement on the Role of Physiotherapy in Pulmonary Rehabilitation in the Indian Context.
Post COVID-19 sequelae includes breathlessness, weakness, fatigue, decreased exercise tolerance and impaired quality of life. Physiotherapy based rehabilitation program is an essential component for post COVID-19 patients in facilitating maximum functional recovery. Expert consensus statements are available from the developed countries. ⋯ This consensus statement was developed by expert panel across India. Published literatures were appraised and used to prepare the recommendations. This is the first of its kind of work providing preliminary guidelines for post COVID-19 physiotherapy.
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J Assoc Physicians India · Dec 2020
Observational StudyStatus of Health-care Workers in Relation to COVID-19 Infection: A Retrospective Study in a Level 4 COVID Hospital in Eastern India.
Healthcare workers (HCWs) have a high risk of acquiring SARSCoV- 2 infection, due to repeated occupational exposure, long working hours, stress and fatigue. In India, there is lack of data regarding the prevalence of COVID-19 amongst HCWs due to absence of routine screening programme within the hospital premises. We have designed this study in order to improve our understanding of the incidence of SARS-CoV2 within the health care workers working in a level 4 COVID hospital in Kolkata. ⋯ Heath care workers are at higher risk of being exposed to SARS-CoV2 and could potentially has a role in transmission in and out of the hospital. Hence, routine screening of both symptomatic as well as asymptomatic hospital staff is essential for early diagnosis to prevent transmission of COVID 19 infection.
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J Assoc Physicians India · Nov 2020
Coronavirus Disease-19 (COVID-19) and Heart Failure: Current Perspective.
COVID-19 has been the biggest pandemic which the world has seen in recent times. The SARS-Cov-2 infection has the potential to cause multi-organ dysfunction. Though the virus predominantly affects the lungs, it can affect the heart in myriad ways. ⋯ Early recognition and prompt management is the need of the hour to prevent any mortality and morbidity. Summary: COVID-19 can affect the heart in many ways. This article describes the mechanisms, clinical presentations and management of heart failure caused by COVID-19 infection.