Biological psychiatry
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Biological psychiatry · Jul 1999
Randomized Controlled Trial Clinical TrialThe effect of acute tryptophan depletion and fenfluramine on quantitative EEG and mood in healthy male subjects.
Efforts to model putative serotonergic deficits associated with affective disorders have frequently involved acute tryptophan depletion (ATD) as a manipulation strategy aimed at lowering brain serotonin synthesis. In an attempt to widen the scope of the measurement probes used in these investigations, the central actions of ATD and a subsequent dose of fenfluramine were examined via utilization of quantitative electroencephalography (EEG) and mood ratings. ⋯ Quantitative EEG measurements may be a promising method for studying the central mechanisms underlying serotonin-mediated changes in mood and behavior.