Biological psychiatry
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Biological psychiatry · Feb 2002
Randomized Controlled Trial Clinical TrialClinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disorders.
The objective of the current study was to examine possible clinical predictors of positive response to lamotrigine or gabapentin monotherapy in treatment-refractory affectively ill patients. ⋯ In this highly treatment-refractory population, lamotrigine appeared most effective for male patients with fewer prior medication trials. Gabapentin monotherapy, although not better than placebo, appeared most effective in those with younger age and lower baseline weight. These preliminary data in a treatment refractory subgroup may help in the further definition of the range of clinical utility of these widely used anticonvulsants.