Biological psychiatry
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Biological psychiatry · Nov 2005
Reduced anterior cingulate glutamate in pediatric major depression: a magnetic resonance spectroscopy study.
Anterior cingulate cortex has been implicated in the pathogenesis of major depressive disorder (MDD). With single voxel proton magnetic resonance spectroscopy, we reported reductions in anterior cingulate glutamatergic concentrations (grouped value of glutamate and glutamine) in 14 pediatric MDD patients versus 14 case-matched healthy control subjects. These changes might reflect a change in glutamate, glutamine, or their combination. ⋯ These findings provide confirmatory evidence of anterior cingulate glutamate alterations in pediatric MDD.