Biological psychiatry
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Biological psychiatry · Mar 2010
Randomized Controlled Trial Clinical TrialDeep brain stimulation for intractable obsessive compulsive disorder: pilot study using a blinded, staggered-onset design.
Prior promising results have been reported with deep brain stimulation (DBS) of the anterior limb of the internal capsule in cases with severe obsessive compulsive disorder (OCD) who had exhausted conventional therapies. ⋯ This pilot study suggests that DBS of the ventral capsule/ventral striatum region is a promising therapy of last resort for carefully selected cases of severe and intractable OCD. Future research should attend to subject selection, lead location, DBS programming, and mechanisms underpinning therapeutic benefits.