Revista médica de Chile
-
Revista médica de Chile · Aug 1996
Multicenter Study Clinical Trial[Tropisetron for the prevention of nausea and vomiting during chemotherapy: multicenter clinical study].
The antiemetic effect of tropisetron was studied in 97 cancer patients (67 men, 30 women) receiving cisplatin in doses of 75 mg/m2 or higher. On 279 chemotherapy cycles studied (max 6 per patient) 5 mg of tropisetron was administered once a day i.v on day 1 and p.o. on days 2 to 6. Efficacy preventing vomiting and nausea was measured in 24 hour period as: complete control O episodes, major control 1 to 2 episodes, minor control 3 to 4 episodes and no control 5 or more episodes. ⋯ We conclude that tropisetron allows satisfactory control of acute and delayed vomiting in a high percentage of patients treated with high doses of cisplatin. The drug does not have significant secondary effects. Tropisetron administration in only one daily dose implies an evident advantage and a treatment cost reduction.
-
Revista médica de Chile · Aug 1996
Clinical Trial[Predictor indices of early extubation in mechanical ventilation in patients treated with heart surgery].
Following open heart surgery, most patients are ventilated for 12 to 24 hours to obtain a period of hemodynamic stability and to reduce the work of breathing. Some authors have proposed criteria to guide early extubation and have proposed physiologic parameters to predict which patients will be able to breathe spontaneously. ⋯ Pulmonary function parameters and blood gases measured during a T piece trial are not good predictors of early extubation in cardiac surgery.