Revista médica de Chile
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Revista médica de Chile · Aug 2000
Clinical Trial Controlled Clinical Trial[Treatment of hirsutism with spironolactone and with spironolactone plus dexamethasone].
Spironolactone has an anti androgenic effect, inhibiting the binding of androgens to their receptor. This antagonistic effect is the basis for the use of spironolactone in the treatment of hirsutism. ⋯ Spironolactone is effective and safe in the treatment of hirsutism. Androgenic supression did no increases its effectiveness, underscoring the peripheral anti androgenic activity os spironolactone.