Revista médica de Chile
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Revista médica de Chile · Jan 2002
[Association between cleft lip/palate phenotype and non syndrome microsatellite markers located in 6p, 17q and 19q].
In the search of the major genes responsible for the genetic etiology of Nonsyndromic Cleft Lip and Palate (NSCLP), an association study between this malformation and four molecular markers, F13A1 and EDN1 (6p), D17S579 (17q) and BCL3 (19q), was done. ⋯ Our results support the hypothesis of the existence of cleft susceptibility regions in 6p and 17q. The small significance of BCL3, suggests that ethnicity can influence the interactions between involved genes.