Revista médica de Chile
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Revista médica de Chile · Jun 2024
Review Case Reports[Review of Multiple Endocrine Neoplasia Type 1 Based on a Clinical Case].
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disease with an estimated prevalence of 2 per 100,000. This disease is caused by a mutation in the tumor suppressor gene MEN1, which is located on chromosome 11 and codifies the menin protein. It is characterized by a predisposition of parathyroids, enteropancreatic, and anterior pituitary tumors, affecting the quality of life and lifespan of those who have the disease. ⋯ Pancreatic and parathyroid surgery were performed, and function substitution therapies were initiated. Discussion: The diagnosis is established in the presence of two or more defining NEM1 tumors or at least one associated with compatible genetic testing or a first-degree relative with a history of MEN1. Screening and surveillance in patients with confirmed MEN1 diagnosis would enable the reduction of the disease burden, with a nonclear impact on lifespan.
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Revista médica de Chile · Jun 2024
Review[Updates in General Management and Frequent Complications Following Adult Liver Transplant].
Liver transplantation (LT) is a cost-effective therapy for advanced liver disease. Although LT significantly improves long-term survival, it requires strict control of immunosuppressants and their potential complications. Several available immunosuppressive drugs include glucocorticoids, calcineurin inhibitors, mycophenolate, mTOR inhibitors, and anti-CD25 antibodies. ⋯ Appropriate treatment of the underlying etiology is essential, especially in autoimmune diseases, hepatitis B and C virus infection. Lifestyle changes must be encouraged in all patients, and alcohol consumption avoided (especially in alcohol use disorder). Due to the increased risk of cancer, neoplasms must be actively monitored, as well as osteoporosis and other metabolic disorders such as diabetes and cardiovascular disease.
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Revista médica de Chile · Jun 2024
Association between body mass index and all-cause mortality in older people: A prospective analysis of the Chilean National Health Survey 2009-2010.
There is a divergence in the results of studies that have explored the association between body mass index (BMI) and health outcomes in different contexts. ⋯ Older people categorized as underweight and obese II had a higher risk of all-cause mortality than their normal-weight peers, regardless of confounding factors.
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Revista médica de Chile · Jun 2024
[Expert Validation of the FACT-C Survey for Measuring Quality of Life in Chilean Patients Diagnosed with Colorectal Cancer].
In Chile, there is limited information regarding the effects on the quality of life of patients undergoing colorectal resective surgery. Although the GES guideline of management of Colorectal Cancer (2013) includes a quality-of-life survey, presented in a non-translated version to Spanish, without instructions regarding its application method, and recently validated (2023). On the other hand, post-surgical and oncological follow-ups focus on evaluating symptoms, signs, and complementary tests associated with recurrences, leaving the non-standardized evaluation of quality of life to the discretion of the healthcare provider. Therefore, the need arises for a standardized instrument that evaluates the quality of life of patients diagnosed, treated, and monitored for colorectal cancer. ⋯ Our results affirm that the FACT-C survey has an excellent CVC, allowing us to continue with the next stage of the validation process in a sample of Chilean patients to ensure its applicability in our population.
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Revista médica de Chile · Jun 2024
Case Reports[Autologous Stem-Cell Transplantation without Transfusion Support in Jehovah's Witness Patients. A case series].
Autologous Stem-Cell Transplantation (ASTC) has proven efficacy in several hematological malignancies. The greatest antineoplastic effect achieved with intensified chemotherapy is associated with severe myelotoxicity. The infusion of autologous hematopoietic precursors and transfusion support during the period of aplasia reduces the time and depth of cytopenias, decreasing the risk of bleeding, anemia and life-threatening infections. ⋯ Despite critical hemoglobin and platelet values observed, no serious complications or treatment-related mortality were observed. At the time of the report, all patients were alive and without progression of their neoplasms. Autologous stem-cell transplantation without transfusion support is feasible in centers with experience in this procedure and can benefit JW among other populations.