American journal of hospital pharmacy
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The stability of terbutaline sulfate in an extemporaneous oral liquid formulation refrigerated for 55 days was studied. A suspension was prepared by grinding commercially available 5-mg terbutaline sulfate tablets, adding Purified Water, USP, to form a paste, and then adding Simple Syrup, NF. A control solution was prepared from analytical grade terbutaline sulfate powder in Simple Syrup, NF. ⋯ On day 55, the mean percentages of the initial terbutaline sulfate concentrations remaining were 103.8% in the suspension and 91.7% in the solution. Color, odor, and pH of the samples did not change appreciably, and colony counts of bacteria were within acceptable limits. An extemporaneously prepared liquid preparation of terbutaline sulfate in Simple Syrup, NF, is stable under the conditions studied for up to 55 days; however, since microbiological testing was not performed on day 55, it is recommended that the preparation be stored for no longer than 30 days.