Scandinavian journal of clinical and laboratory investigation
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Scand. J. Clin. Lab. Invest. · Nov 1988
Intravenous 133Xe clearance in preterm neonates with respiratory distress. Internal validation of CBF infinity as a measure of global cerebral blood flow.
An intravenous 133Xe clearance technique is described, giving very low values of global cerebral blood flow (CBF infinity) in mechanically ventilated, preterm infants. External monitoring of the chest is used to estimate the arterial input function to the brain, with a modified correction to allow for increased recirculation due to right-to-left shunting. ⋯ Fifteen-minute clearance data gave better precision than 8-min data. The modified chest curve correction was partly effective in a case of extreme right-to-left shunting.