Scandinavian journal of clinical and laboratory investigation
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Scand. J. Clin. Lab. Invest. · May 2011
Comparative StudyComparison of hyperbaric oxygen and medical ozone therapies in a rat model of experimental distal colitis.
Previous studies have shown that hyperbaric oxygen (HBO) is effective in reducing the severity of acute distal colitis (ADC). Ozone therapy (OT) reduces inflammation in several pathological conditions. We aimed to compare the effects of HBO therapy and OT in an experimental ADC rat model. ⋯ Our data showed that the therapeutic effect of OT is more pronounced than that of HBO therapy. Its possible effect is by means of decreasing inflammation, edema, and oxidative stress. These findings also suggest that it is possible to improve the outcome of ADC by using ozone therapy as an adjuvant therapy.