Scandinavian journal of clinical and laboratory investigation
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Scand. J. Clin. Lab. Invest. · Jun 2014
Comparative StudyLow dose of hydroxyethyl starch impairs clot formation as assessed by viscoelastic devices.
High doses of the synthetic colloid hydroxyethyl starch (HES) used for plasma expansion have been associated with impaired haemostasis and hypocoagulation. Less is known about effects on clot formation in the low haemodilutional range (< 40%). This study evaluated the effects of low haemodilution with HES and albumin on coagulation using two different viscoelastic methods. ⋯ There is an adverse effect on clot formation even at low grade haemodilution with both albumin and HES. The effect on coagulation is significantly more pronounced with HES than with albumin.