Scandinavian journal of clinical and laboratory investigation
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Scand. J. Clin. Lab. Invest. · Apr 2017
Comparative StudyEffects of hemolysis and lipemia interference on kaolin-activated thromboelastography, and comparison with conventional coagulation tests.
The effects of hemolysis and lipemia on thromboelastography (TEG) analysis have been scarcely evaluated in human samples, and neglected in clinical practice. We aimed to investigate the effects of in vitro mechanical hemolysis and lipemia on TEG analysis and conventional coagulation tests. Twenty-four healthy volunteers were enrolled in the study. ⋯ Bias values of platelet count at moderate to severe hemolysis and lipemia exceeded the CLIA allowable limits. In conclusion, the detection of TEG was in general more affected by mechanical hemolysis than plasma coagulation tests. Pre-analytical variables should be taken into account when unexpected TEG results are obtained.