The Journal of otolaryngology
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Randomized Controlled Trial
Preincisional infiltration of tonsils with ropivacaine in post-tonsillectomy pain relief: double-blind, randomized, placebo-controlled intraindividual study.
To determine whether pre-emptive ropivacaine has an influence on postoperative pain in adult patients undergoing tonsillectomy. ⋯ Based on the present findings, preincisional infiltration of ropivacaine 2% appears to be effective against both early and late postoperative pain, especially on swallowing, following tonsillectomy in adults.
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To document the most important postoperative adenotonsillectomy morbidities, with an emphasis on prolonged hospitalization and readmissions. ⋯ We attribute this improvement to our use of electrocautery-based techniques not only for tonsillectomy but also for adenoidectomy.
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Aminoglycoside antibiotics are some of the most commonly used agents for treating gram-negative bacterial infections. They are extremely efficacious but can result in ototoxicity. It has been postulated that the mechanism inducing damage is the formation of oxygen free radicals. Many compounds have been employed in an attempt to reduce aminoglycoside-induced hearing loss. We endeavour to do likewise using sodium thiosulphate. This free radical scavenging agent has a proven ability to minimize cochlear damage owing to the chemotherapeutic agent cisplatin. ⋯ We were unable to demonstrate that sodium thiosulphate can attenuate gentamicin-induced ototoxicity. Furthermore, we observe that the susceptibility to hearing loss varies considerably between individual C57 mice. Consequently, we hold some degree of reservation with the use of this model to assess the benefit of prospective rescue agents.