Zhonghua fu chan ke za zhi
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Zhonghua Fu Chan Ke Za Zhi · Jul 1994
Comparative Study[The antimetastatic effects of BJA-II on nude mice with highly metastatic human ovarian carcinoma].
Nude mice with highly metastatic human ovarian carcinoma were treated with BJA-II. This new agent was made in our institute. Twenty-four experimental mice were divided into 4 groups with 6 mice each. ⋯ The influences on the immunofunction of the host were observed: the increase of the peripheral WBC count, the increase of NK cell activity, the increase in the ratio of spleen weight to body weight, and the histiocyte increase in the lymph node sinuses, etc. All of these findings were better demonstrated in the BJA-II group than in the cisplatin group. The results indicate that BJA-II is provided with the effectiveness of inhibiting tumor growth, is antimetastatic and is capable of increasing the immunofunction of the host.