Science
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In the report "Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro," by N. Horiuchi et al. (11 Dec., p. 1566), the caption for figure 1 was inadvertently omitted. The figure is reprinted below with the caption. [See Fig. 1. in Source PDF].
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Follicle-stimulating hormone (FSH) is a glycoprotein essential for gonadal development and steroidogenesis. Recent studies suggest that deglycosylation of FSH results in the formation of antagonistic proteins that are capable of binding to gonadal receptors but that are devoid of bioactivity. ⋯ These findings provide the first demonstration of naturally occurring circulating antihormones. These FSH antagonists may play an important role in the physiology and pathophysiology of the gonads.