South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
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The long-term anti-arrhythmic efficacy of lorcainide (R15 889) was studied in 20 ambulatory postmyocardial infarction patients. Lorcainide reduced the frequency of ventricular ectopic beats by more than 70% and 90% in 17 and 11 of the patients respectively. ⋯ On electrocardiographic examination, the P-R interval, QTc interval and QRS duration were prolonged, and T-wave changes were noted while the patients were receiving lorcainide. Lorcainide seems to be a useful addition to the available anti-arrhythmic agents, and should form part of the armamentarium against ventricular ectopic activity.
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Psychogenic cough tic is a troublesome complaint. The cough is a noisy bark or honking, repeated frequently while the child is awake, but absent during sleep. Clinical and laboratory findings are negative, and cough suppressants and other medications are ineffective. ⋯ School phobia is frequently a contributory cause, but other psychological problems must also be considered. Treatment is usually by suggestion and identification of the underlying psychological problem. In some cases tranquillizers may be required.
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The toxicity of ferrous sulphate is discussed, with particular reference to fibrosis and stricturing of the stomach. This does not occur in every case, but occasionally, in spite of adequate treatment, ferrous sulphate produces local damage similar to that caused by acid. ⋯ Gastrectomy is often necessary when severe scarring and fibrosis have resulted in damage to the stomach. The need for long-term follow-up of these patients is an important aspect of treatment.