Southern medical journal
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Southern medical journal · Aug 1997
Conscious sedation with high-dose midazolam for pediatric gastrointestinal endoscopy.
Midazolam is used frequently to sedate children for gastrointestinal endoscopy. The sedative dosage of intravenous midazolam commonly reported in children is up to 0.3 mg/kg. We hypothesized that larger doses of midazolam could be used for pediatric endoscopy. ⋯ Intravenous doses of midazolam > 0.3 mg/kg can be used for conscious sedation in children.
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Southern medical journal · Aug 1997
ReviewNondepolarizing neuromuscular blocking drugs in the intensive care unit: a clinical review.
The use of nondepolarizing neuromuscular blocking drugs (NDNMBDs) via continuous infusion in the intensive care unit (ICU) is gaining in popularity. Several new NDNMBDs have been developed recently; these drugs vary in their elimination, metabolism, and half-lives. ⋯ The use of NDNMBDs is progressively increasing in ICUs. Proper understanding of normal neuromuscular physiology, clinical pharmacology, and drug interactions is essential to optimize patient care and to minimize the risk of adverse reactions.
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Southern medical journal · Aug 1997
Case ReportsPulmonary blastomycosis with acute respiratory failure as predominant clinical feature.
Two previously healthy young adults came to our community hospital with rapidly progressive respiratory failure. Investigation confirmed Blastomyces as the responsible etiologic agent. Despite adequate antifungal chemotherapy and intensive supportive care, both patients died, one within 24 hours and the other after 14 days. Overwhelming infection with Blastomyces dermatitidis can cause acute respiratory failure, possibly the adult respiratory distress syndrome, even in immunocompetent hosts.