Southern medical journal
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Southern medical journal · Mar 2010
Randomized Controlled TrialIntrathecal sufentanil for intraoperative and postesophagectomy pain relief.
The present study compares the analgesic properties of intrathecal (IT group) and intravenous (IV group) sufentanil in postoperative pain relief. ⋯ Preoperative IT sufentanil can be used as a booster to achieve rapid and effective analgesia not only during the operation but also during the immediate postoperative period.
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Southern medical journal · Mar 2010
Case ReportsMetformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy.
Chronic metformin use results in vitamin B12 deficiency in 30% of patients. Exhaustion of vitamin B12 stores usually occurs after twelve to fifteen years of absolute vitamin B12 deficiency. ⋯ Failure to diagnose the cause of the neuropathy will result in progression of central and/or peripheral neuronal damage which can be arrested but not reversed with vitamin B12 replacement. To my knowledge, this is the first report of metformin-induced vitamin B12 deficiency causing neuropathy.