Indian heart journal
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Indian heart journal · Mar 2019
Meta AnalysisEffect of morphine use on oral P2Y12 platelet inhibitors in acute myocardial infarction: Meta-analysis.
Morphine is the recommended analgesic in acute myocardial infarction (AMI). This recommendation has come under scrutiny because of possible slow uptake of oral antiplatelet agents. ⋯ Co-administration of morphine with P2Y12 inhibitors possibly decreases their efficacy in platelet inhibition. However, this did not translate into higher adverse outcomes because of low event rates, inadequate for analysis. A large randomized study is needed to evaluate the narcotic-P2Y12 interaction.