Medizinische Monatsschrift für Pharmazeuten
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Med Monatsschr Pharm · Jul 2010
Review[Roflumilast: a new approach to therapy of chronic obstructive pulmonary disease].
Roflumilast, a new inhibitor of phosphodiesterase 4, showed moderate efficacy in clinical trials with patients suffering from chonic obstructive pulmonary disease (COPD). Improvement of pulmonary function is predominantly attributed to antiinflammatory effects with decrease in mucus secretion and less exacerbations. Diarrhoea, headache and nausea are typical adverse events.