Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
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Beijing Da Xue Xue Bao · Jun 2003
[Therapeutic effect of dexamethasone and mannitol on global brain ischemia-reperfusion injury in rats].
To determine the effect of dexamethasone and mannitol on reperfusion injury after global brain ischemia in rats. ⋯ Dexamethasone aggravates brain ischemic-reperfusion injury, mannitol is effective for reducing brain ischemia-reperfusion injury, and application of the combined agents is the most effective treatment.
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Beijing Da Xue Xue Bao · Jun 2003
[Changes in long-term synaptic plasticity in the spinal dorsal horn of neuropathic pain rats].
To observe the change in induction of long-term potentiation (LTP) of C-fiberevoked potentials in the spinal dorsal horn of neuropathic pain rats, examine the changes in plasticity of synaptic transmission, and explore the effects and mechanisms of central sensitization and neuropathic pain following noxious stimulation or nerve injury. ⋯ These data suggest that the nerve injury itself is likely to induce a state of hyperexcitability at the spinal nociceptive synapses, and further support the notion that the long-term synaptic plasticity and the central sensitization may contribute to the development of neuropathic pain.