Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
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Beijing Da Xue Xue Bao · Jun 2008
[Effect of acute progressive normovolemic hemodilution with lactated Ringer's, gelatin and hydroxyethyl starch on coagulation and survival rate in rabbits].
To observe acute progressive normovolemic hemodilution with lactated Ringer's, gelatins, and hydroxyethyl starch in vivo and in vitro on blood coagulation and survival rate and time in rabbits. ⋯ With in vitro hemodilution, the initiation of coagulation is unaffected or decreased. However with in vivo hemodilution, initiation of coagulation is accelerated or unchanged. The discrepancy between in vivo and in vitro hemodilution, indicates an unknown internal mechanism to promote initiation of coagulation. Hemodilution makes the toughness of clot soften. and the longest survival time in profound hemodilution associated with hydroxyethyl starch.
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Beijing Da Xue Xue Bao · Jun 2008
[Total hepatic ischemia-reperfusion-induced lung injury in rats and protective effects of melatonin].
To explore total hepatic ischemia-reperfusion(I/R)-induced lung injury in rats,its related mechanism and the protective effects of melatonin on lungs. ⋯ Total hepatic I/R led to severe lung injury. The aggravation of lipid peroxidation, reduced capability of scavenging free radical and aggravation of apoptosis were important factors causing hepatic I/R induced lung injury. Melatonin had protective effect on lung injury induced by total hepatic I/R, which was mediated by anti-oxidation and anti-apoptosis, but the relationship between melatonin's protective effects and activation of ERK1/2 signal transduction pathway remained to be explored.