Nihon Geka Gakkai zasshi
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Nihon Geka Gakkai zasshi · Jun 1985
[Influence of post-vagotomy duodenogastric reflux on gastric mucosal structure].
There has not come to any definite conclusion on morphological changes in post-vagotomy gastric mucosa. And, it was reported that duodenogastric reflux in consequence of pyloroplasty or gastroenterostomy could aggravate these gastric mucosal changes. To elucidate this problem, 34 Wistar male rats were subjected to either truncal vagotomy, duodenogastric reflux procedure (transection of the lower part of the duodenum and gastrojejunostomy), or truncal vagotomy with duodenogastric reflux procedure. ⋯ Rats subjected to duodenogastric reflux also showed chronic ulceration in the prepyloric region on the lesser curvature and hyperplasia of gastric glands. However, no remarkable changes were observed in the stomach of rats with vagotomy. These results indicate that chronic influence of postvagotomy duodenogastric reflux can lead to severe gastritis as well as altered structure of gastric mucosa.