Mayo Clinic proceedings
-
Mayo Clinic proceedings · Feb 2025
Early-Onset Gastrointestinal Cancers and Metabolic Risk Factors: Global Trends From the Global Burden of Disease Study 2021.
To explore the increasing incidence of gastrointestinal (GI) cancers and related risk factors in younger patients. ⋯ Our research highlights a significant increase in early-onset GI cancer, emphasizing the need for a strategy that includes controlling risk factors, particularly metabolic risk factors, adoption of effective screening methods, and effective cancer management.
-
Mayo Clinic proceedings · Feb 2025
Comparison of Muscle Strength and Cardiorespiratory Fitness in Relation to Cardiovascular and All-Cause Mortality: The Copenhagen City Heart Study.
To compare the association between muscle strength (MS), cardiorespiratory fitness (CRF), and all-cause and cardiovascular disease (CVD) mortality. ⋯ Both CRF and MS are inversely associated with CVD mortality and all-cause mortality, but of the 2, CRF confers stronger protection.
-
Mayo Clinic proceedings · Feb 2025
Bias Experiences and Burnout: A Multispecialty, Cross-Sectional Survey of Residents and Fellows at a Multisite US Academic Medical Center.
To explore associations of bias frequency, sources, and types with burnout in a large, multispecialty sample of residents and fellows and to determine whether and how odds of burnout change after adjustment for bias experiences in multiple demographic subgroups. ⋯ Self-reported bias experiences relate strongly to trainee burnout. Some bias sources may be more strongly associated with burnout than others. More frequent bias experiences could account, at least in part, for higher odds of burnout in some demographic subgroups.
-
Mayo Clinic proceedings · Feb 2025
Individual and Combined Association Between Healthy Behaviors and All-Cause and Premature Mortality: A 22-Year Follow-up Cohort.
To analyze the impact of individual and combined healthy behaviors on all-cause and premature mortality risk in Mexican adults. ⋯ Over 22 years, adopting a healthier life was linked with lower all-cause and premature mortality risk, decreasing with the clustering of one additional healthy behavior. Law and policy changes as well as efforts to address the root causes of not adopting healthy behaviors in low- and middle-income countries, such as creating structural conditions for people to engage in physical activity or strong social marketing to raise awareness of the daily consumption of fruits and vegetables, are needed for improving health and delaying mortality.
-
Mayo Clinic proceedings · Feb 2025
Body Fat Distribution and Ectopic Fat Accumulation as Mediator of Diabetogenic Action of Lipid-Modifying Drugs: A Mediation Mendelian Randomization Study.
To investigate the causal relationship between various lipid-modifying drugs and new-onset diabetes, as well as the mediators contributing to this relationship. ⋯ Our findings support the hypothesis that liver fat and gluteofemoral adipose tissue play a mediating role in the prodiabetic effects of HMGCR and APOB inhibition, as well as in the antidiabetic effects of LPL enhancement.