Mayo Clinic proceedings
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To identify coagulation risk factors in patients with calciphylaxis and the relationship between anticoagulation use and overall survival. ⋯ Laboratory testing reveals a strikingly high prevalence of severe thrombophilias in patients with calciphylaxis, underscoring the importance of congenital and acquired thrombotic propensity potentially contributing to the pathogenesis of this disease. These findings may have therapeutic implications; however, to date, survival differences did not vary by therapeutic choice.