Mayo Clinic proceedings
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Clinical and histopathologic features of 15 cases of diffuse fasciitis with eosinophilia are reviewed. The patients experienced an inflammatory scleroderma-like illness without Raynaud's phenomenon or internal organ involvement. Polyarthritis and carpal tunnel syndrome were observed. ⋯ Histopathologic features are discussed, as is their relationship to other forms of localized scleroderma. None of the 12 patients treated with corticosteroids has had complete resolution of the skin changes after a median follow-up of 10 months. Unusual associated diseases--acute myelomonocytic leukemia and an evolving myeloproliferative disorder--were observed in two patients.
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Mayo Clinic proceedings · Jul 1980
Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease.
Nonalcoholic steatohepatitis is a poorly understood and hitherto unnamed liver disease that histologically mimics alcoholic hepatitis and that also may progress to cirrhosis. Described here are findings in 20 patients with nonalcoholic steatohepatitis of unknown cause. The biopsy specimens were characterized by the presence of striking fatty changes with evidence of lobular hepatitis, focal necroses with mixed inflammatory infiltrates, and, in most instances, Mallory bodies; Evidence of fibrosis was found in most specimens, and cirrhosis was diagnosed in biopsy tissue from three patients. ⋯ Most patients were moderately obese, and many had obesity-associated diseases, such as diabetes mellitus and cholelithiasis. Presence of hepatomegaly and mild abnormalities of liver function were common clinical findings. Currently, we know of no effective therapy.
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Mayo Clinic proceedings · Feb 1978
Biography Historical ArticleWas Peter Parker a competent clinician?
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This case report is that of a 53-year-old man without current evidence of significant psychiatric disorder who requested treatment for dependence on chewing-tobbaco. During his successful treatment in the Alcoholism and Drug Dependence Unit, we noted several similarities between his tobacco chewing and other drug dependencies.