Journal of orthopaedic surgery and research

The most recent articles from: J Orthop Surg Res July 2011

J Orthop Surg Res · Jul 2011

Comparative Study

Alendronate (ALN) combined with osteoprotegerin (OPG) significantly improves mechanical properties of long bone than the single use of ALN or OPG in the ovariectomized rats.

Alendronate (ALN) is the most common form of bisphosphonates used for the treatment of osteoporosis. Osteoprotegerin (OPG) has also been shown to reduce osteoporotic changes in both humans and experimental animals after systemic administration. The aim of this current study was to test if the anti-resorption effects of ALN may be enhanced when used in combination with OPG. ⋯ The combined use of OPG-Fc and ALN may be a new treatment strategy for reversing bone loss and restoring bone quality in osteoprotic disorders.

expand abstract… mark as read…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.