The Review of scientific instruments
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Machine vision is widely used in an industrial environment today. It can perform various tasks, such as inspecting and controlling production processes, that may require humanlike intelligence. The importance of imaging technology for biological research or medical diagnosis is greater than ever. ⋯ There is a strong need for the development of a digital microfluidics system integrated with machine vision for innovative biological research today. In this paper, we show how machine vision can be applied to digital microfluidics by demonstrating two applications: machine vision-based measurement of the kinetics of biomolecular interactions and machine vision-based droplet motion control. It is expected that digital microfluidics-based machine vision system will add intelligence and automation to high-throughput biological imaging in the future.
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As the measuring head of a fetal pulse oximeter must be attached to the head of the fetus inside the mother's uterus during labor, testing, and developing of fetal pulse oximeters in real environment have several difficulties. A fetal phantom could enable evaluation of pulse oximeters in a simulated environment without the restrictions and difficultness of medical experiments in the labor room. Based on anatomic data we developed an adjustable fetal head phantom with three different tissue layers and artificial arteries. ⋯ With the phantom we investigated the sensitivity of a custom-designed wireless pulse oximeter at different pulsation intensity and artery diameters. The results showed that the oximeter was capable of identifying 4% and 2% changes in diameter between the diastolic and systolic point in arteries of over 0.2 and 0.4 mm inner diameter, respectively. As the structure of the phantom is based on reported anatomic values, the results predict that the investigated custom-designed wireless pulse oximeter has sufficient sensitivity to detect the pulse waves and to calculate the R rate on the fetal head.
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An air flow transducer for controlling heated humidifiers used in neonatal artificial ventilation, suitable for in-line application in monopatient breathing circuits, is described here. The sensor is built with two nominally identical bipolar junction transistors, with different packages, as hot elements operated at a regulated constant voltage. The operation principle is based on the differential convective heat power exchanged with the fluid stream due to the different thermal conductivities of the transistors' packages. ⋯ The differential nature of the output allows to obtain repeatabilities in the order of 2% for fluid temperatures between 20 and 25 degrees C and of about 6% if the fluid temperature lies in the range of 15-35 degrees C. The relatively long time constant, in the order of 20+/-5 s, makes the sensor suitable for average flow rate measurements. Using the sensor's output as a control variable of a heated humidifier for artificial ventilation, the relative humidity of gases varies by only 20% in the flow rate range of the sensor (from 95% to 75%), whereas the same parameter shows a variation of about 40% (from 100% to 60%) with the same humidifier without flow control.
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This article introduces a low-cost phase detection radar aimed at measuring the human heartbeat and respiration signals without any physical connections to the human body. A continuous-wave radar targeting the chest will detect the phase difference, resulted by the time-varying target position of the heartbeat, between the transmitted signal and the reflected signal. We have tested the developed radar to measure the heartbeat and respiration signals at a distance of about 40 cm from the chest.
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Comparative Study
Noncontact simultaneous dual wavelength photoplethysmography: a further step toward noncontact pulse oximetry.
We present a camera-based device capable of capturing two photoplethysmographic (PPG) signals at two different wavelengths simultaneously, in a remote noncontact manner. The system comprises a complementary metal-oxide semiconductor camera and dual wavelength array of light emitting diodes (760 and 880 nm). By alternately illuminating a region of tissue with each wavelength of light, and detecting the backscattered photons with the camera at a rate of 16 frames/wavelength s, two multiplexed PPG wave forms are simultaneously captured. ⋯ Bland and D. Altman [Lancet 327, 307 (1986); Statistician 32, 307 (1983)] test, the noncontact device to be comparable to a contact device as a monitor of heart rate. We highlight some considerations that should be made when using camera-based "integrative" sampling methods and demonstrate through simulation, the suitability of the captured PPG signals for application of existing pulse oximetry calibration procedures.